Kinase(s)

 

Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and many more. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinase is the name given to an enzyme that catalyzes the transfer of a phosphate group from ATP to another molecule. Kinases can be broadly separated by their substrate into protein and lipid kinases with the protein kinases being further classified based on their cellular location and the specific amino acid(s) they phosphorylate; cytoplasmic threonine, receptor tyrosine kinases (RTKs), and serine/threonine.

The prominent roles that kinases play in cell division have made them attractive targets for both immunosuppressant drugs and cancer therapeutics. Kinases are highly druggable, and account for over 25% of targets screened by the pharmaceutical industry. Currently, there are over 25 kinase inhibitors that have been approved for clinical use by the FDA, including rapamycin, which was discovered in the 1960s. It was not until three decades later, however, that the target of rapamycin was discovered to be a serine/threonine kinase that was named mammalian target of rapamycin (mTOR). Today rapamycin is approved as an immunosuppressant and a number of mTOR inhibitors are being investigated as treatments for various forms of cancer.

BPS offers a wide selection of kinases, kinase substrates and kinase inhibitors. Our kinases are validated through rigorous QC testing and are suitable for use in nearly all in vitro kinase assays. We also offer kinase inhibitor screening services.

References:

1.   Cohen, P. Nat. Rev. Drug Disc. 2002; 1: 309-315.
2.   Ballou, L.M., et al., J. Chem. Biol. 2008 1(1-4): 27-36.
3.   Loewith, R., et al., Genetics. 2011; 189(4): 1177-1201.

 

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Catalog#SizeProduct NamePrice
40029 10 µg CAMK4, GST-tag
$370
40044 10 µg CAMKK1, GST-tag
$370
40046 10 µg CAMKK2, GST-tag
$370
40100 10 µg CDK1/CyclinA2, GST-tag
$365
40454 10 µg CDK1/CyclinB1, GST-tag
$345
41101 10 µg CDK2 (no tag)/CyclinA2, His-GST-tags
$345
40101 10 µg CDK2/CyclinA2, GST-tag
$345
40102 10 µg CDK2/CyclinE1, GST-tag
$365
40103 10 µg CDK3/CyclinE1, GST-tag
$345
40094 20 µg CDK4(EE,T172A)/Cyclin D1, His-tag
$345
40104 10 µg CDK4/CyclinD3, GST-tag
$365
40105 10 µg CDK5/p25, GST-tag
$345
40095 10 µg CDK5/p35, GST-tag
$345
40097 10 µg CDK6/CyclinD1, His-tag, GST-tag
$365
40206 20 µg CDK6/CyclinD3, His-tags
$345
40098 10 µg CDK7/CyclinH1/MNAT1, His-tags
$365
40106 10 µg CDK9/CyclinK, GST-tag
$365
40307 10 µg CDK9/CyclinT1, GST-tag
$345
27036 5 mg Cediranib
$190
40617 10 µg Ceramide Kinase, FLAG-tag
$415
40619 300 reactions CERK Substrate
$405
40618 150 reactions CERK Substrate
$220
27614-2 25 mg CHIR-99021 (CT99021)
$460
27614-3 100 mg CHIR-99021 (CT99021)
$905
27614-1 5 mg CHIR-99021 (CT99021)
$180

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