Kinase(s)

 

Protein phosphorylation is a key aspect in the regulation of a large number of cellular processes including cellular division, metabolism, signal transduction, and many more. There are over 500 kinases encoded by the human genome and it has been estimated that kinases regulate approximately 50% of cellular functions. Kinase is the name given to an enzyme that catalyzes the transfer of a phosphate group from ATP to another molecule. Kinases can be broadly separated by their substrate into protein and lipid kinases with the protein kinases being further classified based on their cellular location and the specific amino acid(s) they phosphorylate; cytoplasmic threonine, receptor tyrosine kinases (RTKs), and serine/threonine.

The prominent roles that kinases play in cell division have made them attractive targets for both immunosuppressant drugs and cancer therapeutics. Kinases are highly druggable, and account for over 25% of targets screened by the pharmaceutical industry. Currently, there are over 25 kinase inhibitors that have been approved for clinical use by the FDA, including rapamycin, which was discovered in the 1960s. It was not until three decades later, however, that the target of rapamycin was discovered to be a serine/threonine kinase that was named mammalian target of rapamycin (mTOR). Today rapamycin is approved as an immunosuppressant and a number of mTOR inhibitors are being investigated as treatments for various forms of cancer.

BPS offers a wide selection of kinases, kinase substrates and kinase inhibitors. Our kinases are validated through rigorous QC testing and are suitable for use in nearly all in vitro kinase assays. We also offer kinase inhibitor screening services.

References:

1.   Cohen, P. Nat. Rev. Drug Disc. 2002; 1: 309-315.
2.   Ballou, L.M., et al., J. Chem. Biol. 2008 1(1-4): 27-36.
3.   Loewith, R., et al., Genetics. 2011; 189(4): 1177-1201.

 

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Catalog#SizeProduct NamePrice
40022 10 µg AMPK (A1/B1/G3), His-tags
$595
40703 5 µg AMPK (A1/B2/G1), His-tag
$470
40023 10 µg AMPK (A1/B2/G1), His-tags
$595
40704 5 µg AMPK (A2/ B1/G1), His-tag
$470
40024 10 µg AMPK (A2/B1/G1), His-tags
$595
40705 5 µg AMPK (A2/B2/G1), His-tag
$470
40026 10 µg AMPK (A2/B2/G1), His-tags
$595
40706 5 µg AMPK (A2/B2/G2), His-tag
$470
40027 10 µg AMPK (A2/B2/G2), His-tags
$595
40010 10 µg aRAF, His-tag
$355
40028 10 µg Ask1, GST-tag
$370
40520 1 mg ATF2, GST-tag
$260
40178 10 µg AURORA C, GST-tag
$370
40004 10 µg Aurora Kinase A
$345
40002 10 µg Aurora Kinase B, GST-tag, His-tag
$345
27064 50 mg Axitinib
$75
40180 10 µg Axl, GST-tag
$345
48688 96 reactions B-Raf(V600E) Kinase Assay Kit
$495
40401 10 µg BLK, GST-tag
$370
40402 10 µg BMX, GST-tag
$345
40533 10 µg BRAF (V600E), GST-tag
$345
40065 10 µg BRAF, GST-tag
$345
41237 10 µg BRAF, His-Tag (R444-DESC)
$345
40005 10 µg BRAF/p50, FLAG-tag
$345
40403 10 µg BRK, GST-tag
$345

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