Rapamycin

Catalog #

27062

$135 *

Size: 50 mg

Qty

Bulk/Custom

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*US Pricing only. For international pricing, please contact your local distributor.

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Description

Immunosuppressant, related to FK-506, but without calcineurin inhibitory activity even when complexed to FK-506 binding protein. Selectively blocks signaling that leads to p70 S6 kinase activation (IC50 = 50 pM).

This product has been cited 3 times.

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Synonyms

Rapamune, Sirolimus

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Product Data Gallery

Product Info

Storage and Usage

Citations3

Purity

≥99%

Format

White to off-white crystalline solid, granular or powder

Formula

C₅₁H₇₉NO₁₃

914.17 Da

Solubility

Soluble in DMSO at 200 mg/ml; soluble in ethanol at 50 mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.

CAS Registry #

53123-88-9

References

Terada, N., et al. J. Biol. Chem. 268: 12062-12068 (1993).

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Rapamycin

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