Rapamycin
Catalog #
27062
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Description
Immunosuppressant, related to FK-506, but without calcineurin inhibitory activity even when complexed to FK-506 binding protein. Selectively blocks signaling that leads to p70 S6 kinase activation (IC50 = 50 pM).
This product has been cited 3 times.
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Synonyms
Rapamune, Sirolimus
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Product Data Gallery
Product Info
Storage and Usage
Citations3
Purity
≥99%
Format
White to off-white crystalline solid, granular or powder
Formula
C51H79NO13
MW
914.17 Da
Solubility
Soluble in DMSO at 200 mg/ml; soluble in ethanol at 50 mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-20 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
CAS Registry #
53123-88-9
References
Terada, N., et al. J. Biol. Chem. 268: 12062-12068 (1993).