K252a
Catalog #
27033
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Description
K252a is a general kinase inhibitor that inhibits PKA (Ki = 18 nM), PKC (Ki = 25 nM), PKG (Ki = 20 nM), CaMK (Ki = 1.8 nM), and phosphorylase kinase (IC50 = 1.7 nM). It functions by acting competitively with ATP and noncompetitively with the substrate.
Product Info
Storage and Usage
Citations
Purity
≥99%
Format
White to pale yellow powder.
Formula
C27H21N3O5
MW
467.5 Da
Solubility
Soluble in DMSO at 100 mg/ml; poorly soluble in ethanol.
CAS Registry #
97161-97-2
References
1. Kase, H., et al. Biochem. Biophys. Res. Commun. 142: 436-440 (1987).
2. Hashimoto, Y., et al. Biochem. Biophys. Res. Commun. 181: 423-429 (1991).
2. Hashimoto, Y., et al. Biochem. Biophys. Res. Commun. 181: 423-429 (1991).