Fasudil

Catalog #

27029

$120 *

Size: 250 mg

Qty

Bulk/Custom

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Description

Monohydrochloride form of HA-1077. Inhibits a number of kinases, including ROCK I (IC50 = 10.7 µM), ROCK II (IC50 = 1.9 µM), MAPK1 (IC50 = 5 µM), and PKCRK2 (IC50 = 4 µM). Weaker inhibitor of PKC (IC50 = 425 µM) and MLCK (IC50 = 95 µM) .

This product has been cited 2 times.

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Synonyms

HA-1077, Monohydrochloride Salt, 1-(5-Isoquinolinesulfonyl)homopiperazine, HCl, Eril, AT-877

Product Info

Storage and Usage

Citations2

Purity

≥99%

Format

White crystalline powder.

Formula

C₁₄H₁₇N₃O₂S•HCl

327.8 Da

Solubility

Very soluble in water, up to about 200 mg/ml ; soluble in DMSO up to about 95 mg/ml; not soluble in ethanol; addition of an aqueous solution of this monohydrochloride salt into a buffer solution may significantly alter its solubility.

CAS Registry #

105628-07-7

References

Davies, S.P. et al. Biochem. J. 351: 95-105 (2000).

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