c-Mer Kinase Assay Kit

Catalog #

79660

$535 *

Size: 96 Reactions

Qty

Bulk/Custom

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Description

c-Mer (MERTK) is a member of the TAM receptor kinases and plays an important role in cell proliferation/survival, adhesion/migration, and regulation of inflammatory cytokine release. Along with other members of this family, Axl and TYRO3, c-Mer is part of an emerging class of innate immune checkpoints participating in antitumoral immunity. Thus, it has been suggested that c-Mer inhibition could be a promising immunotherapeutic approach in cancer treatment. The c-Mer Kinase Assay Kit is designed to measure c-Mer activity for screening and profiling applications using ADPGlo® as a detection reagent.

Need us to run inhibitor screens or profile your compounds against c-Mer? Check out our Kinase Screening Services.

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Synonyms

Tyrosine-protein kinase Mer, MERTK, Receptor tyrosine kinase, MerTK

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Product Info

Storage and Usage

Citations

Assay Kit Format

Luminescent

Materials Required But Not Supplied

ADP-Glo (Promega #V6930), Dithiothreitol (DTT, 1 M; optional), Microplate reader capable of reading luminescence, Adjustable micropipettor and sterile tips, 30°C incubator

Format

COMPONENTS:

UniProt #

Q12866

References

Akalu, Y.T., et. al. Immunological Reviews 276:165-177 (2017)

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c-Mer Kinase Assay Kit

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