KAT5 (TIP60), GST-Tag Recombinant
Catalog #
79422
$410
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Description
Recombinant human KAT5 (lysine acetyltransferase 5) also known as TIP60, full length and containing the kinase domain. This construct contains an N-terminal GST-tag. This recombinant protein was affinity purified and is kinase active.
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Synonyms
cPLA2 interacting protein ESA1 HTATIP, HTATIP1, PLIP, TIP
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Product Info
Storage and Usage
Citations
Species
Human
Construct
KAT5 (GST-Full length)
Host Species/Expression System
Sf9
Purity
≥90%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 50 mM NaCl, 10 mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol
MW
88 kDa
Specific Activity
30 pmol/min/µg
Genbank #
NM_006388
UniProt #
Q92993
Background
KAT5 or K (lysine) acetyltransferase 5 is a signaling protein that belongs to the MYST family of histone acetyl transferases (HATs). KAT5 was originally isolated as an HIV-1 TAT-interactive protein that plays an important role in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins (1). KAT5 protein is a histone acetylase that is involved in DNA repair and apoptosis and plays an important role in signal transduction. KAT5 acts as a cofactor of TAT that is involved in the regulation of HIV gene expression. KAT5 is also a co-regulator of transcription factors that either promote or suppress tumorigenesis (2).
References
1. Kamine, J. et.al. Virology. 1996; 216: 357-366.
2. Gorrini, C. et al. Nature. 2007 448:1063-1067.