(-)-JQ1

Catalog #: 27335
Size: 25 mg
$455
MW: 457.0 kDa
CAS Registry #: 1268524-71-5
Formula:

C23H25ClN4O2S

Background:
(-)-JQ1 is the inactive stereoisomer of the potent, cell-permeable, small molecule bromodomain inhibitor (+)-JQ1 that competitively binds to acetyl-lysine recognition motifs. (+)-JQ1 competitively binds to the bromodomain displacing the BRD4 fusion oncoprotein from chromatin, which induces squamous differentiation and specific anti-proliferative effect in BRD4-dependent cell lines and patient-derived xenograft models. However, study results have shown that (-)-JQ1 fails to significantly interact with any bromodomain tested and exhibits inhibition against BRD4(1) with and IC50 of 10,000 nM.
Synonym(s):
(R)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate
Biological Activity:
(-)-JQ1 showed no inhibition of BRD4-dependent NMC cells.
Solubility:
Soluble in DMSO or ethanol at 100 mM
Storage / Stability:
Store at or below -80°C. Stable for less than 6 months when stored as directed.
Warning(s):
Avoid freeze/thaw cycles.
Scientific Category:
Bromodomain
Product Type:
Inhibitor
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Product Datasheets

27335_Lot141010.pdf