Mouse JARID1B (KDM5B, PLU-1), FLAG-tag Recombinant
Catalog #
50122
$450
*
●
●
Purchase
Description
Mouse JARID1B, also known as PLU-1 and KDM5B (GenBank Accession No. NM_152895), a.a. 2-751 with N-terminal FLAG-tag, MW = 86 kDa, expressed in Sf9 cells via a baculovirus expression system.
●
Synonyms
JARID1B, PLU-1, KDM5B, Retinoblastoma-Binding Protein 2 Homolog 1, RBP2-H1, CT31, Cancer/Testis Antigen 31, PLU-1, Jumonji, AT Rich Interactive Domain 1B, Lysine-Specific Demethylase 5B
●
Product Data Gallery
10% SDS-PAGE Coomassie Staining
Product Info
Storage and Usage
Citations
Species
Mouse
Host Species/Expression System
Sf9 insect cells
Purity
≥50%
Format
Aqueous buffer solution
Formulation
45 mM Tris-HCl, pH 8.0, 124 mM NaCl, 2.4 mM KCl, 90 ?g/ml FLAG peptide, 10% glycerol, and 3 mM DTT
MW
86 kDa
Amino Acids
2–751
Genbank #
NM_152895
UniProt #
Q80Y84
Background
Histone demethylase that demethylates Lys-4 of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 Lys-9 or H3 Lys-27. Demethylates trimethylated, dimethylated and monomethylated H3 Lys-4. Acts as a transcriptional corepressor for FOXG1B and PAX9. Favors the proliferation of breast cancer cells by repressing tumor suppressor genes such as BRCA1 and HOXA5. In contrast, may act as a tumor suppressor for melanoma.
References
1. Yamane K, et al. (2007). Mol. Cell 25 (6): 801–12.
2. Barrett A, et al. (2007). Int. J.Cancer 121 (2): 265–75.
Application Reference:
An high-throughput in vivo screening system to select H3K4-specific histone demethylase inhibitors
(2014)
Powered by Bioz
6405 Mira Mesa Blvd. Suite 100
San Diego, CA 92121
858-202-1401
San Diego, CA 92121
858-202-1401
Products are for Research Use Only
COMPANY
Copyright © 2024
BPS Bioscience, Inc.
All rights reserved.
Diagrams on this website are created with BioRender.com.