Irsogladine
Catalog #
27754
$140
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Description
Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
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Synonyms
MN 1695; 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate
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Product Data Gallery
Product Info
Storage and Usage
Citations
Format
White crystalline powder
Target(s)
PDE4
Formula
C9H7Cl2N5
MW
256.1 Da
Solubility
Soluble in DMSO
CAS Registry #
57381-26-7
Background
Irsogladine is a selective PDE4 inhibitor that facilitates gap junction intercellular communication through muscarinic acetylcholine receptor binding. It is a potent inhibitor of angiogenesis in wild-type and plasminogen activator-deficient mice. Inhibition of PDE4 prevents the hydrolysis of cAMP, an important secondary messenger molecule that is heavily involved in signal transduction.
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