(S)-HDAC-42
Catalog #: 27208 

Size: 1 mg

Structure:

CAS Registry #: 935881-37-1

Purity: ≥95%

Chemical Formula: C₈H₂₀N₂O₃

Molecular Weight: 312.4

Description: (S)-HDAC-42 is a strong inhibitor of HDACs. It decreases the viability of prostate
cancer cell lines by increasingthe expression of p21 and the acetylation of histone H3 while
decreasing Akt phosphorylation and Bcl-XL expression. The inhibitor suppresses the growth of
PC-3 tumor xenografts, reducing levels of phospho-Akt and Bcl-XL protein in tumors.

Appearance: A crystalline solid

Solubility: Soluble in ethanol, DMSO and DMF, which should be purged with an inert gas.
Solubility in these solvents is ~20 mg/ml. For organic solvent-free aqueous solutions, prepare
by directly dissolving the crystalline compound in aqueous buffers. Do not store aqueous
solutions for more than one day.

Biological Activity: (S)-HDAC-42 inhibits HDACs with IC₅₀ = 16 nM in vitro.

Storage/Stability: Store at or below -20°C for up to two years.

Quality Control: The purity was determined by HPLC analysis.

References:
1. Lu, Q., et al., J. Med. Chem. 2005; 48: 5530-5535
2. Kulp, S.K., et al., Clin. Cancer Res. 2006; 12(17): 5119-5206.

PRODUCT DATA SHEETS
Lot 120524

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