HNHA
Catalog #: 27206 

Size: 10 mg

Structure:

CAS Registry #: 926908-04-5

Purity: ≥98%

Chemical Formula: C₁₇H₂₁NO₂S

Molecular Weight: 303.4

Description: HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity. HNHA
induces histone hyperacetylation and p21 transcription with inhibition of cell cycle progression in
human fibrosarcoma HT1080 cells. In in vivo murine xenographs, HNHA is equally as effective
as SAHA in inhibiting tumor growth. HNHA inhibits HUVEC growth and prevents tube formation
and migration in response to VEGF. Also HNHA blocks retinal neovascularization and choroidal
angiogenesis in mice.

Appearance: A crystalline solid

Solubility: Soluble in ethanol, DMSO and dimethyl formamide at 20 mg/ml. Sparingly soluble
in aqueous buffers. First dissolve in DMSO, then dilute with aqueous buffer of choice. Do not
store aqueous solutions for more than one day.

Biological Activity: HDAC is inhibited by HNHA with IC₅₀ = 100 nM.

Storage/Stability: Store at or below -20°C for up to two years.

Quality Control: The purity was determined by HPLC analysis.

References:
1. Kim, D.H., et al., Biochem. Biophys., Res. Commun. 2007; 356: 233 -328.
2. Kim, J.H., et al., Molecular Pharmaceutics 2009; 6(2): 513-519.

PRODUCT DATA SHEETS
Lot 120403

Data shown is lot-specific. For specific information on other lots, please contact us.