HC Toxin
Catalog #: 27209

Size: 500 μg

Structure:

CAS Registry #: 83209-65-8

Purity: ≥95%

Chemical Formula: C₂₂H₃₄N₄O₆

Molecular Weight: 450.5

Description: HC Toxin is a reversible, cell-permeable inhibitor of HDACs. It is a cyclic
tetrapeptide first isolated from C. carbonum, a maize pathogen. It up-regulates the expression of
15-lipoxygenase-1 in colorectal cancer cells and has been shown to induce fetal hemoglobin in
human primary erythroid cells.

Appearance: A crystalline solid

Solubility: Soluble in methanol, purged with an inert gas. Solubility in methanol is
approximately 10 mg/ml. For organic solvent-free aqueous solutions, prepare by directly
dissolving the crystalline compound in aqueous buffers. Do not store aqueous solutions for
more than one day.

Biological Activity: HC Toxin inhibits HDACs with an IC₅₀ = 30 nM.

Storage/Stability: Store at or below -20°C for up to two years.

Quality Control: The purity was determined by HPLC analysis.

References:
1. Brosch, G., et al., Plant Cell. 1995; 7: 1941-1950.
2. Darkin-Rattray, SJ, et al., Proc. Natl. Acad. Sci. USA. 1996; 93(23): 13143-13147.
3. Kamitani, H., et al., Carconogenesis. 2001; 22(1): 187-191.
4. Cao, H., et al., Am. J. Hematol. 2006; 81: 981-983.
5. Walton, JD., Phytochemistry. 2006; 67: 1406-1413.

PRODUCT DATA SHEETS
Lot 120529

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