Catalog #: 27400
Size: 10 mg
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CAS Registry #: N/A
Chemical Formula: C23H25ClN4O2S
Molecular Weight: 456.99
Description: (+)-JQ1 is a specific inhibitor of the BET family of acetyl-lysine recognition motifs,
including the BRD2, BRD3, BRD4 and BRDT bromodomains.
Appearance: A crystalline solid.
Solubility: Soluble in DMSO or ethanol; insoluble in water.
Biological Activity: (+)-JQ1 has been shown to inhibit BRD4 (BD1) with a Kd of 50 nM, and
BRD4 (BD2) with a Kd of 90 nM.
Storage/Stability: Store at or below +4°C.
Quality Control: The purity was determined by HPLC.
Reference(s): Filippakopoulos P., et al. Nature. 468(7327):1067-73 (2011).
PRODUCT DATA SHEETS
Data shown is lot-specific. For specific information on other lots, please contact us.
Manufactured, marketed and sold with authorization from Tensha Therapeutics, lnc. Patent
Pending relating to PCT Publ. No. WO/201"L/L43669, and any related U.S. and foreign patents
and patent applications.