INCB024360 Analog
Catalog #
27338-1
$190
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Description
INCB024360 analog is an orally available hydroxyamidine and inhibitor of indoleamine 2,3- dioxygenase (IDO1), with an IC50 of 10 nM. It shows little activity against other related enzymes such as IDO2 or tryptophan 2,3-dioxygenase (TDO). INCB024360 analog displays potential immunomodulating and antineoplastic activities.
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Synonyms
4-[(3-chloro-4-fluoroanilino)-nitrosomethylidene]-1,2,5-oxadiazol-3-amine, IDO inhibitor
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥98%
Format
White powder
Formula
C9H7ClFN5O2
MW
271.6 Da
Solubility
Soluble in DMSO.
Biological Activity
INCB024360 analog has been reported to restore and increase the proliferation of
various immune cells including dendritic cells, NK cells, and T cells in vitro and in vivo.
CAS Registry #
914471-09-3
References
1. Koblish, HK., et al., Molec. Cancer Therapeutics. 2010; 9: 489-498.
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