Immunotherapy

 

The immune system is a system of cells and organs whose function is to defend an organism from foreign pathogens. With the ability to mount a response against virtually any foreign material and return to a quiescent state following neutralization of the threat, this fascinating organ system displays remarkable specificity and plasticity. To achieve this, there is a multifaceted balancing act between the many activators and suppressors that maintains homeostasis of perhaps the body’s most complex organ system.

Activation of the immune system involves a number of checkpoints in order to ensure proper activation. For instance, T cell activation requires binding of the T cell receptor to the MHC antigen, yet this interaction alone is not sufficient for producing a T cell response. Full T cell activation and inactivation requires the coordination of a multitude of co-stimulatory and inhibitory signals. For example, T cell activation can result from the combination of MHC:TCR and B7-1:CD28 interaction. In contrast, B7-1 binding to CTLA4 results in an inhibitory signal that prevents activation.

Given its diverse function and the fact that the immune system plays a role in virtually all human diseases, immunotherapy has become an important approach for the treatment of numerous diseases. Immunotherapy is defined as the treatment of disease by inducing, enhancing, or suppressing an immune response. This often involves targeting immunoreceptors, such as those discussed above, with small molecule inhibitors/activators or immune system components, including antibodies or antibody fragments (Fab). Immunotherapies have shown efficacy in the treatment of cancer, autoimmune diseases, inflammatory diseases, and more.

BPS Bioscience offers many purified, soluble immunoreceptors involved in key immunosignaling pathways. Additionally, we offer a number of assay kits that can be used to screen for inhibitors of protein-protein interaction, as well as neutralizing antibodies to serve as positive controls for inhibition.

References:

1.  Pardoll, D.M., Nat. Rev. Cancer. 2012; 12: 252-264.
2.  Lesterhuis, W.J., et al., Nat. Rev. Drug. Disc. 2011; 10: 591-600.

Immunotherapy Subcategories

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Catalog#SizeProduct NamePrice
79002 100 μg B7-1 (CD80), FLAG-Avi-His-Tag (Mouse)
$300
71150 100 µg B7-2 (CD86), Fc fusion (Human)
$300
71159 50 μg B7-2 (CD86), Fc fusion, Biotin labeled (Human) HiP™
$405
71130 100 µg B7-H2 (CD275, ICOSL), Fc fusion (Human) HiP™
$300
79119 100 μg B7-H2, Avi-His-Tag
$300
79300 50 µg B7-H2, Avi-His-Tag, Biotin-Labeled
$405
71144 100 µg B7-H4, His-tag (Human)
$300
71129 50 µg B7-H4, His-tag, Biotin-labeled (Human) HiP™
$405
71148 100 µg B7-H5 (VISTA), Fc fusion (Human) HiP™
$300
71327 50 µg B7-H5 Fc fusion, Avi-Tag, Biotin-labeled (Human)
$405
79259 100 ml BPS Medium 1
$95
79260 100 ml BPS Medium 7
$95
71141 100 µg BTLA(CD272), Fc fusion (Human)
$300
72008 96 reactions BTLA:HVEM[Biotinylated] Inhibitor Screening Assay Kit
$995
40254 10 µg c-Mer, GST-tag (Human)
$375
80413 50 µg CBL-B (Y363F), His-tag, Biotin-labeled (Human)
$355
80412 50 µg CBL-B, His-tag, Biotin-labeled (Human)
$355
72231 50 μg CD112, Fc-Fusion, Avi-Tag, Biotin-labeled (Human)
$405
71197 100 μg CD112, His-tag (Human) HiP™
$300
71234 50 μg CD112, His-tag, Biotin-labeled (Human) HiP™
$405
79116 100 μg CD112R, Fc-Fusion, Avi-Tag (Human) HiP™
$300
79270 50 μg CD112R, Fc-Fusion, Avi-Tag, Biotin-Labeled (Human) HiP™
$405
72510 100 μg CD113, Fc-Fusion (IgG1), Avi-Tag
$300
71170 100 µg CD137 (4-1BB), Fc fusion (Human) HiP™
$300
71171 50 µg CD137 (4-1BB), Fc Fusion, Biotin-labeled (Human) HiP™
$405

Items 51 to 75 of 401 total

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