Immunotherapy

 

The immune system is a system of cells and organs whose function is to defend an organism from foreign pathogens. With the ability to mount a response against virtually any foreign material and return to a quiescent state following neutralization of the threat, this fascinating organ system displays remarkable specificity and plasticity. To achieve this, there is a multifaceted balancing act between the many activators and suppressors that maintains homeostasis of perhaps the body’s most complex organ system.

Activation of the immune system involves a number of checkpoints in order to ensure proper activation. For instance, T cell activation requires binding of the T cell receptor to the MHC antigen, yet this interaction alone is not sufficient for producing a T cell response. Full T cell activation and inactivation requires the coordination of a multitude of co-stimulatory and inhibitory signals. For example, T cell activation can result from the combination of MHC:TCR and B7-1:CD28 interaction. In contrast, B7-1 binding to CTLA4 results in an inhibitory signal that prevents activation.

Given its diverse function and the fact that the immune system plays a role in virtually all human diseases, immunotherapy has become an important approach for the treatment of numerous diseases. Immunotherapy is defined as the treatment of disease by inducing, enhancing, or suppressing an immune response. This often involves targeting immunoreceptors, such as those discussed above, with small molecule inhibitors/activators or immune system components, including antibodies or antibody fragments (Fab). Immunotherapies have shown efficacy in the treatment of cancer, autoimmune diseases, inflammatory diseases, and more.

BPS Bioscience offers many purified, soluble immunoreceptors involved in key immunosignaling pathways. Additionally, we offer a number of assay kits that can be used to screen for inhibitors of protein-protein interaction, as well as neutralizing antibodies to serve as positive controls for inhibition.

References:

1.  Pardoll, D.M., Nat. Rev. Cancer. 2012; 12: 252-264.
2.  Lesterhuis, W.J., et al., Nat. Rev. Drug. Disc. 2011; 10: 591-600.

Immunotherapy Subcategories

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Catalog#SizeProduct NamePrice
71125 100 µg B7-1 (CD80), Fc fusion (Human) HiP™
$310
71114

25 µg
50 µg
500 µg

B7-1 (CD80), Fc fusion, Biotin-labeled (Human) HiP™
Starting at:
$250
71261 100 µg B7-1 (CD80), FLAG-Avi-His-Tag
$310
79002 100 μg B7-1 (CD80), FLAG-Avi-His-Tag (Mouse)
$310
100040 50 µg B7-1 (Woodchuck), Fc-fusion (Human), Avi-Tag, Biotin-labeled
$420
71150 100 µg B7-2 (CD86), Fc fusion (Human)
$310
71159 50 μg B7-2 (CD86), Fc fusion, Biotin labeled (Human) HiP™
$420
71130 100 µg B7-H2 (CD275, ICOSL), Fc fusion (Human) HiP™
$310
79119 100 μg B7-H2, Avi-His-Tag
$310
79300 50 µg B7-H2, Avi-His-Tag, Biotin-Labeled
$405
71144 100 µg B7-H4, His-tag (Human)
$310
71129 50 µg B7-H4, His-tag, Biotin-labeled (Human) HiP™
$420
71148 100 µg B7-H5 (VISTA), Fc fusion (Human) HiP™
$310
71327 50 µg B7-H5 Fc fusion, Avi-Tag, Biotin-labeled (Human)
$420
79365 100 μg B7-H7, Fc-Fusion, Avi-Tag
$305
79366 50 μg B7-H7, Fc-Fusion, Avi-Tag, Biotin-Labeled
$405
79667 96 reactions BAFF:BCMA[Biotinylated] Inhibitor Screening Assay Kit
$765
79467 50 μg BCMA, Fc-fusion (IgG1), Avi-Tag, Biotin-Labeled HiP™
$420
79259 100 ml BPS Medium 1
$100
79260 100 ml BPS Medium 7
$100
79385 100 ml BPS Medium 8
$100
79476 2 Vials BTLA / NFAT - Luciferase Reporter - Jurkat Recombinant Cell Line
$8,000
71141 100 µg BTLA(CD272), Fc fusion (Human)
$310
100033 100 µg BTLA, Fc Fusion, Avi-Tag HiP™
$310
100047 50 µg BTLA, Fc Fusion, Avi-Tag, Biotin-Labeled HiP™
$420

Items 51 to 75 of 490 total

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