NLG919

Catalog #

27337-2

$590 *

Size: 50 mg

Qty

Bulk/Custom

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Description

NLG919 is an orally available potent inhibitor of the indoleamine-2,3- dioxygenase (IDO) pathway, a crucial pathway involved in allergic inflammation that mediates immunosuppressive effects through metabolization of tryptophan to kynurenine. NLG919 affects differentiation and proliferation of T cells by inducing downstream signaling via GCN2, mTOR and AHR, with values of Ki = 7 nM and EC50 = 75 nM. NLG919 is being investigated for the treatment of immunosuppression associated with cancer.

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Synonyms

1-cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanol, IDO inhibitor

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Product Data Gallery

Product Info

Storage and Usage

Citations

Purity

≥98%

Format

White powder

Formula

C₁₈H₂₂N₂O

282.4 Da

Solubility

Soluble in DMSO at 15 mg/ml.

Biological Activity

NLG919 potently blocks IDO-induced T cell suppression and restored T cell responses with a reported ED50 of 80 nM in vitro. NLG919 reduced the concentration of plasma and tissue kynurenine by ~50% after a single dose in mice. NLG919 enhanced the antitumor responses of naïve, resting pmel-1 T-cells to vaccination with cognate hgp100 peptide plus CpG-1826 in IFA in mice bearing B16F10 tumors.

CAS Registry #

1402836-58-1

References

1. Driessens, G., et al., J. Immunother. Cancer. 2014; 2(Suppl 3):195.
2. Nayak, A., et al. J. Immunother. Cancer. 2014; 2(Suppl 3): 250.

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