SIRP-α / HEK293 Recombinant Cell Line
Recombinant HEK293 cell constitutively expressing full length human SIRPa (#NM_080792). Surface expression is confirmed by flow cytometry.
Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
This cell line has been screened using the (Cat. #LT07-118) to confirm the absence of Mycoplasma contamination. MycoAlert Assay Control Set (Cat # LT07-518) was used as a positive control.
SIRP alpha (CD172A, PTPNS1, SIRP a) is a member of the signal-regulatory-protein (SIRP) family, which are transmembrane immunoglobulin receptors that negatively regulate receptor tyrosine kinase-coupled signaling processes. SIRP alpha is expressed predominantly on macrophages and dendritic cells. Interaction with its ligand CD47 mediates signals that blocks phagocytosis (also known as the “don’t eat me” signal).