SIRP-α / HEK293 Recombinant Cell Line

Catalog #
60689
$4,840 *
Size: 2 vials
Qty
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Description

Recombinant HEK293 cell constitutively expressing full length human SIRPa (#NM_080792). Surface expression is confirmed by flow cytometry.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

Synonyms
sirp hek293, sirp a, sirpa, SIRPα cell line, SIRP cell line, CD47 cell line , sirp alpha sirpa
Product Info
Storage and Usage
Citations
Host Cell Line
HEK293
Format
Each vial contains ~2 x 10^6 cells in 1 ml of 10% DMSO in FBS.
UniProt #
P78324
Mycoplasma Testing

This cell line has been screened using the (Cat. #LT07-118) to confirm the absence of Mycoplasma contamination. MycoAlert Assay Control Set (Cat # LT07-518) was used as a positive control.

Background

SIRP alpha (CD172A, PTPNS1, SIRP a) is a member of the signal-regulatory-protein (SIRP) family, which are transmembrane immunoglobulin receptors that negatively regulate receptor tyrosine kinase-coupled signaling processes. SIRP alpha is expressed predominantly on macrophages and dendritic cells. Interaction with its ligand CD47 mediates signals that blocks phagocytosis (also known as the “don’t eat me” signal).

References
1. Lee WY et.al. (2010) The Role of cis Dimerization of Signal Regulatory Protein a (SIRPa) in Binding to CD47. J. Biol. Chem. 285: 37953-37963