PSMA (FOLH1) - CHO Recombinant Cell Line (High, Medium, or Low Expression)

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Catalog #
79641
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Description

Recombinant clonal stable CHO cell line constitutively expressing full length human PSMA protein (Genbank #NM_004476.1). Surface expression of PSMA was confirmed by flow cytometry. Each stable clonal cell line was selected for different levels of PSMA expression to mimic different stages of cancer target cells with various PSMA expression levels.

Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.

Synonyms
FOLH, NAALAD1, PSM
Product Info
Storage and Usage
Citations
Host Cell Line
Chinese Hamster Ovary
Supplied As
Each vial contains ~ 2 x 10^6 cells in 1 ml of FBS + 10% DMSO.
UniProt #
O14818
Mycoplasma Testing
This cell line has been screened using the Quick Test Mycoplasma Detection Kit (Biotool.com, #B39032) to confirm the absence of Mycoplasma contamination.
Background
PSMA (prostate-specific membrane antigen), also known as Folate hydrolase 1 (FOLH1), is expressed at high levels on prostate cancer cells. It has been reported to play a role in tumor progression through the PI3K-Akt and MAPK-ERK1/2 pathways. PSMA/FOLH1 has been used as a target for imaging prostate cancer and is expressed in other tumor types and some normal tissues. Currently, PSMA/FOLH1 is the target of clinical trials of CAR-T cells and bi-specific antibodies.