HVEM - CHO Recombinant Cell Line
Catalog #
79297
$6,500
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Purchase
Description
Recombinant CHO-K1 stably expressing human HVEM (TNF receptor superfamily member 14; TNFRSF14; TR2; ATAR; HVEA; HVEM; CD270; LIGHTR; GenBank Accession #NM_003820).
Purchase of this cell line is for research purposes only; commercial use requires a separate license. View the full terms and conditions.
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Synonyms
HVEM, TNFRSF14, CD270, HVEA, TR2, LIGHTR
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Product Data Gallery
Product Info
Storage and Usage
Citations
Host Cell Line
CHO, Chinese Hamster Ovary
Supplied As
Each vial contains ~ 2 x 10^6 cells in 1 ml of 10% DMSO.
UniProt #
Q92956
Mycoplasma Testing
The cell line has been screened using the metabolite-based Mycoplasma Detection Kit (Biotool #B3903) to confirm the absence of Mycoplasma species.
Background
HVEM (CD270, TNFRSF14) is a human cell surface receptor in the TNF-receptor
superfamily that can act as both a co-stimulatory receptor and a co-inhibitory receptor
expressed on the surface of T cells. Binding of HVEM to one of its ligands, LIGHT
(CD258, TNFSF14) or LTα (lymphotoxin-α), causes a co-stimulatory signal which can
activate lymphoid cells. Interaction with BTLA (CD272) or CD160 causes a co-inhibitory
signal which negatively regulates T-cell immune responses. HVEM has also been shown
to interact with adaptor proteins TRAF2 and TRAF5, and is critical to herpes simplex
virus (HSV) cellular entry.