CD38 (Rat) Inhibitor Screening Assay Kit (Hydrolase Activity)

Catalog #

79690

$765 *

Size: 96 reactions

Qty

Bulk/Custom

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*US Pricing only. For international pricing, please contact your local distributor.

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Description

The Rat CD38 Inhibitor Screening Assay Kit (Hydrolase Activity) is designed to measure the glycohydrolase activity of rat CD38 for screening and profiling applications.

Need us to run inhibitor screens or profile your compounds against CD38 (Rat) (Hydrolase Activity)? Check out our Immunotherapy Biochemical Screening Services.

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Synonyms

Cluster of Differentiation, 38ADPRC1, ADPRC 1, CD38 molecule

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Product Data Gallery

Product Info

Storage and Usage

Citations

Assay Kit Format

Fluorogenic

Materials Required But Not Supplied

Adjustable micropipettor and sterile tips
Fluorescent microplate reader
Rotating or rocker platform

Format

Catalog Number	Component	Amount	Storage
100269	CD38 (Rat)	1 µg	-80°C	Avoid multiple freeze/thaw cycles
	4x CD38 hydrolase buffer	3 ml	-20°C
	CD38 substrate (ε-NAD)	50 µl	-20°C
	Apigenin (50 mM in DMSO)	10 µl	-20°C
79685	Black 96-well plate	1

*The initial concentration of CD38 (Rat) is lot specific and will be indicated on the tube containing the enzyme

Background

CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein that functions as an ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD) glycohydrolase. The major enzymatic activity of CD38 is the hydrolysis of NAD. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic  cells. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia.

References

Koguma, T., et al. Biochim. Biophys. Acta Mol. Cell. Res. 1994. 1223(1): 160-162
Malavasi, F., et al. Physiol. Rev. 2008. 88(3): 841-886

Storage/Stability

Up to 6 months from date of receipt, when stored as recommended.

Instructions for Use

See assay protocol.

Shipping Temperature

-80°C

Warnings

Avoid multiple freeze/thaw cycles

Disclaimers and Limitations

BPS Bioscience assay kits are validated using the listed components according to our specific protocol. Any deviations to kit components or protocols, such as using different proteins, cell/tissue lysates, or buffers (including using the same component from other commercial sources) will void any warranties on the performance of the assay kit and is not recommended.

End-users should immediately report any issues to [email protected] upon receipt of the kit, such as missing components, damaged vials, no dry ice, etc.

Scientific Category

Immunotherapy

Regulatory Status

Research Use Only