CD38 Inhibitor Screening Assay Kit (Cyclase Activity)

Catalog #: 71275
Size: 96 reactions
$765
Background:
CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein. It is also known as ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD+) glycohydrolase. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic B cells. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia.
Description:
The CD38 Inhibitor Screening Assay Kit (Cyclase Activity) is designed to measure the cyclase activity of CD38 for screening and profiling applications. The CD38 assay kit comes in a convenient 96-well format, with purified recombinant CD38 enzyme, its substrate nicotinamide guanine dinucleotide (NGD+), and CD38 assay buffer for 100 enzyme reactions. In addition, the kit includes the CD38 inhibitor quercitin for use as a positive control.
Synonym(s):
cluster of differentiation 38, cyclic ADP ribose hydrolase
Format:

COMPONENTS:

Instructions for use:
See product datasheet for detailed assay protocol.
Storage / Stability:
Up to 6 months from date of receipt, when stored as recommended.
Application(s):
Great for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
Reference(s):
Wei, W., et al., World J. Biol. Chem. 2014 5(1):58-67.
Notes:
MATERIALS OR INSTRUMENTS REQUIRED BUT NOT SUPPLIED:

Adjustable micropipettor and sterile tips

Fluorescent microplate reader

Rotating or rocker platform

Scientific Category:
Immunotherapy
Product Type:
Assay Kit
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Product Datasheets

71275.pdf