CD38 Inhibitor Screening Assay Kit (Cyclase Activity)

Catalog #

71275

$890 *

Size: 96 reactions

Qty

Bulk/Custom

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*US Pricing only. For international pricing, please contact your local distributor.

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Description

The CD38 Inhibitor Screening Assay Kit (Cyclase Activity) is designed to measure the cyclase activity of CD38 for screening and profiling applications. The CD38 assay kit comes in a convenient 96-well format, with purified recombinant CD38 enzyme, its substrate nicotinamide guanine dinucleotide (NGD+), and CD38 assay buffer for 100 enzyme reactions. In addition, the kit includes the CD38 inhibitor quercetin for use as a positive control.

Need us to run inhibitor screens or profile your compounds against CD38 (Cyclase Activity)? Check out our Immunotherapy Biochemical Screening Services.

This product has been cited 1 time.

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Synonyms

cluster of differentiation 38, cyclic ADP ribose cyclase, activity assay kit

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Product Data Gallery

Product Info

Storage and Usage

Citations1

Assay Kit Format

Fluorogenic

Materials Required But Not Supplied

Adjustable micropipettor and sterile tips

Fluorescent microplate reader

Rotating or rocker platform

Format

Catalog Number	Reagent	Amount	Storage
71277	CD38, His-Tag (Human), HiP™	25 µg	-80°C	Avoid multiple freeze/thaw cylces!
	3x CD38 assay buffer	4 ml	-20°C
	CD38 substrate NGD+	50 µl	-20°C
	Quercetin (50 mM DMSO)	100 µl	-20°C
79685	Black 96-well plate	1	Room Temp.

UniProt #

P28907

Background

CD38, a differentiation antigen of B lymphocytes, is a type II integral membrane protein. It is also known as ADP-ribosyl cyclase and nicotinamide adenine dinucleotide (NAD+) glycohydrolase. Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in various cells, including pancreatic B cells. CD38 is a prognostic biomarker for acute B lymphoblastic leukemia.

References

Wei, W., et al., World J. Biol. Chem. 2014 5(1):58-67.