Anti-CTLA4 Neutralizing Antibody

Catalog #: 71212
Size: 100 µg
$475
Species: Human
Host Species: Freestyle 293 cells
MW: 150 kDa
Isotype: IgG1κ
Description:

Neutralizing recombinant human monoclonal antibody recognizing the extracellular domain of CTLA4 and blocking binding of CTLA4 to B7.1 and B7.2. This antibody recognizes human CTLA4 but does not bind to murine CTLA4. This antibody has not been tested for cross-reactivity with other species

Synonym(s):
Cytotoxic T-lymphocyte-associated protein 4, CD152
Endotoxin Level:
<1 EU/µg
Specific Activity:
IC50 = 5 nM
Assay Conditions:
Antibody was added to CTLA4:B7.1 binding assay at various concentrations. Assay was done according to BPS Cat. #72009 protocol.
Formulation:
8 mM phosphate, 110 mM NaCl, 2.2 mM KCl, pH 7.4, and 20% glycerol
Purification:
Protein A affinity chromatography from HEK293 supernatants.
Format:
Aqueous buffer solution.
Storage / Stability:
Stable for at least 12 months at -80°C.
Application(s):
Useful for inhibition of CTLA4:B7 interactions.
Reference(s):

1. Linsley, P.S., et al., J. Exp. Med. 1991; 174(3): 561-569.
2. Hurwitz, A.A., et al., Canc. Res. 2000; 60: 2444-2448.

Warning(s):
Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 – 0.5%) at 4°C, stable for 2 weeks.
Scientific Category:
Immunotherapy
Product Type:
Antibody
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Product Datasheets

71212.pdf