Anti-CD47 Antagonist Antibody

Catalog #
79065-2
$310 *
Size: 100 µg
Qty
*US Pricing only. For international pricing, please contact your local distributor.
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Description

Anti-CD47 recombinant human antagonist antibody recognizing the SIRP-α or SIRP-ү binding region of human CD47. This antibody has not been tested for cross-reactivity with any other species.

Product Info
Storage and Usage
Citations
Species
Human
Isotype
IgG1
Clonality
Monoclonal
Host Species/Expression System
HEK293
Purification
Protein A affinity chromato-graphy from HEK293 supernatants.
Formulation
8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
MW
Heavy Chain: 51 kDa, Light Chain: 27 kDa
Background

Cluster of Differentiation 47, or CD47, plays an essential role in cell growth, death, migration, and adhesion. CD47 binding to SIRP-α mediates phagocytosis by sending a “do not eat me” signal to phagocytes. CD47 proteins are often over expressed by tumor cells as a means for them to escape phagocytosis. As a result, cancerous tumor cells have the ability to proliferate and evade the immune system.

CD47 Antagonist Antibody

References
1. Vernon-Wilson, E.F. et al., Eur. J. Immunol. 2000; 30(8): 2130-2137.

2. Majeti, R. et al., Cell. 2009; 138(2): 286- 299.