Anti-CD47 Antagonist Antibody

Catalog #: 79065-1
Size: 50 µg
$325
Species: Human
Host Species: HEK293
MW: Heavy Chain: 51 kDa, Light Chain: 27 kDa
Clonality: Monoclonal
Isotype: IgG1
Background:

Cluster of Differentiation 47, or CD47, plays an essential role in cell growth, death, migration, and adhesion. CD47 binding to SIRP-α mediates phagocytosis by sending a “do not eat me” signal to phagocytes. CD47 proteins are often over expressed by tumor cells as a means for them to escape phagocytosis. As a result, cancerous tumor cells have the ability to proliferate and evade the immune system.

Description:
Anti-CD47 recombinant human antagonist antibody recognizing the SIRP-α or SIRP-ү binding region of human CD47. This antibody has not been tested for cross-reactivity with any other species.
Formulation:
8 mM Phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Purification:
Protein A affinity chromato-graphy from HEK293 supernatants.
Storage / Stability:
Stable for at least 12 months at -80°C. Protect from light. Avoid freeze/thaw cycles. Store diluted antibody with carrier protein (BSA 0.1 – 0.5%) at 4°C, stable for 2 weeks.
Application(s):
Useful as an antagonist to block CD47 signaling and binding to SIRP-α or SIRP-ү in biochemical assays.
Reference(s):
1. Vernon-Wilson, E.F. et al., Eur. J. Immunol. 2000; 30(8): 2130-2137.

2. Majeti, R. et al., Cell. 2009; 138(2): 286- 299.

Scientific Category:
Immunotherapy
Product Type:
Antibody
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Product Datasheets

79065-1_Lot_170619.pdf