Human Interleukin-1 receptor antagonist Recombinant
Catalog #
90170-A
$130
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Description
Recombinant IL-1RA is a disulfide-linked monomer protein consisting of 153 amino acid residues, and migrates as an approximately 17 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human interleukin-1 receptor antagonist mature chain was expressed in E. coli.
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Synonyms
ILra, MVCD4, IL-1RN, IRAP, IL-1 Receptor Antagonist
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥95% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from 0.2 µm filtered PBS, pH 7.4.
MW
17 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Amino Acids
26–177
Biological Activity
The ED50 as determined by the ability to inhibit the IL-1α mediated cell proliferation in a murine helper T cell line in the presence of 50 pg/mL of IL-1α, is typically 20 - 60 ng/mL.
Genbank #
P18510
UniProt #
P18510
Background
IL1ra is found in the conditioned medium of a variety of cells and is produced by macrophages, monocytes,neutrophils. The soluble form of IL1ra has been shown to be produced by hepatocytes, and to be regulated by pro- inflammatory cytokines.
References
1. Diabetes Care, Sep 2009, 32: 1663 - 1668.
2. N. Engl. J. Med., Jun 2009, 360: 2426 - 2437.
3. Endocrinology, Jun 2009, 150: 2660 - 2667.
2. N. Engl. J. Med., Jun 2009, 360: 2426 - 2437.
3. Endocrinology, Jun 2009, 150: 2660 - 2667.
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