Human Interferon-alpha 2a Recombinant
Catalog #
90158-A
$130
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Description
Recombinant Interferon alpha 2a is a disulfide-linked monomeric protein consisting of 166 amino acid residues, and migrates as an approximately 19 kDa protein under non-reducing conditions and reducing conditions. Optimized DNA sequence encoding Human Interferon-alpha mature chain was expressed in E. coli.
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Synonyms
Interferon Alpha 2a, IFN2a, IFNA, IFNalpha, IFN
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥98% by SDS-PAGE and HPLC
Format
lyophilized protein
Formulation
Lyophilized from 0.2 µm filtered PBS solution, pH 7.0.
MW
19 kDa
Endotoxin Level
<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.
Biological Activity
The activity was determined by a viral resistance assay of Human WISH cells, and was found to be in the range of 1x108 IU/mg.
Genbank #
P01563
UniProt #
P01563
Background
All known subtypes of IFN-alpha show the same antiviral antiparasitic, antiproliferative activities. Human IFN-alpha is also a potent antiviral substance in murine, porcine, and bovine cell systems. IFN-alpha forms are produced by monocytes/macrophages, lymphoblastoid cells, fibroblasts, and a number of different cell types following induction by viruses, nucleic acids, glucocorticoid hormones, and low-molecular weight substances. All IFN-alpha subtypes possess a common conserved sequence region between amino acid positions 115-151 while the amino- terminal ends are variable. Many IFN-alpha subtypes differ in their sequences at only one or two positions. IFN-alpha and IFN-beta are thought to bind to the same receptor. Signal transduction mechanisms elicited after binding of IFN-alpha to its receptors involves tyrosine phosphorylation of various non-receptor tyrosine kinases belonging to the Janus kinases.
References
1. J. Biol. Chem., Sep 2009, 284: 25051 - 25064.
2. J. Biol. Chem., Sep 2009, 284: 24328 - 24340.
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