I-BET-762

Catalog #
27630-1
$225 *
Size: 5 mg
Qty
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Description

I-BET-762 is a small molecule inhibitor of the BET family of bromodomaincontaining proteins. It has been shown to bind to the acetylated lysine recognition motifs on the bromodomain of BET proteins. This binding prevents the interaction of between BET proteins and acetylated histone peptides.

Synonyms
2-[(4S)-6-(4-chlorophenyl)-8-methoxy-1-methyl-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepin-4-yl]-N-ethylacetamide
Product Info
Storage and Usage
Citations
Target(s)
BET
Formula
C22H22ClN5O2

MW
423.9 Da
Solubility
Soluble in Water
CAS Registry #
1260907-17-2
Background
Bromodomains have an important role in the targeting of chromatin-modifying enzymes to specific sites, including methyltransferases, HATs and transcription factors and regulate diverse biological processes from cell proliferation and differentiation to energy homeostasis and neurological processes.
References
Nicodeme E, et al. Nature. 2010 Dec 23;468 (7327):1119-23.