HSP70, His-Tag Recombinant
Catalog #
50287
$385
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Description
Recombinant human HSP70 (human heat shock protein 70), full length encompassing amino acids 1-641(end). This construct contains a C-terminal His-tag (6xHis). The recombinant protein was affinity purified.
This product has been cited 1 time.
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Synonyms
HSP70, Heat Shock Protein 70,
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Product Data Gallery
4-20% SDS-PAGE Coomassie Staining
HSP70 inhibition curve using a chemiluminescent assay (#78414). Representative data only; data may vary by lot.
Product Info
Storage and Usage
Citations1
Species
Human
Construct
HSP70 (1-641(end)-His)
Host Species/Expression System
E. coli
Purity
≥90%
Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 3 mM DTT, 20% glycerol, and variable imidazole
MW
71 kDa
Amino Acids
1-641
Genbank #
NM_005345
UniProt #
P0DMV8
Background
In cooperation with other chaperones, Hsp70 stabilizes preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
References
1. Lee K.J. et al., Exp. Mol. Med. 40 (6), 658-668 (2008).
2. Birtas-Atesoglu E. et al., Clin. Exp. Rheumatol. 26, S96-S98 (2008).
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