HDAC6, GST-tag (Sf9-derived) Recombinant
Recombinant human HDAC6 (histone deacetylase 6), full length encompassing amino acids 1-1215(end). This protein contains an N-terminal GST-tag. A short peptide linker placed between GST and the protein includes a Thrombin Cleavage Site. This recombinant protein was affinity purified.
This product has been cited 137 times.
≥85%
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 0.04% Tween-20, 3 mM DTT, and 20% glycerol
≥290 pmol/min/µg
HDAC6 is a distinct member of the histone deacetylase family, primarily found in the cytoplasm. Unlike other HDACs it targets non-histone proteins. HDAC6 regulates cell motility by deacetylating α-tubulin and helps degrade misfolded proteins through autophagy. Additionally, it influences stress responses and immune signaling by modulating acetylation of key regulatory proteins. Due to its versatile roles, HDAC6 is a promising drug target with potential therapeutic applications in cancer, neurodegenerative diseases, and immune disorders.
1. Li S. et al., Neurology. 41(2), 112-6 (2010).
2. Strausberg, R.L. et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002).
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