HDAC6, FLAG-Tag Recombinant

Catalog #
50056
$495 *
Size: 50 µg
Qty
*US Pricing only. For international pricing, please contact your local distributor.
Purchase
Description

Recombinant human HDAC6 (histone deacetylase 6), full length encompassing amino acids 1-1215(end). This protein contains a C-terminal FLAG-Tag and was affinity purified.

This product has been cited 21 times.

Synonyms
histone deacetylase 6, HDAC-6
Product Info
Storage and Usage
Citations21
Species
Human
Construct
HDAC6 (1-1215(end)-FLAG)
Host Species/Expression System
Sf9
Purity

≥90%

Format
Aqueous buffer solution
Formulation

40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 80 ng/µl FLAG peptide, and 20% glycerol

MW
132 kDa
Amino Acids
1-1215(end)
Specific Activity

≥350 pmol/min/µg.

Genbank #
NM_006044
UniProt #
Q9UBN7
Tag(s)
C-terminal FLAG-tag
Background

HDAC6 is a distinct member of the histone deacetylase family, primarily found in the cytoplasm. Unlike other HDACs it targets non-histone proteins. HDAC6 regulates cell motility by deacetylating α-tubulin and helps degrade misfolded proteins through autophagy. Additionally, HDAC6 influences stress responses and immune signaling by modulating acetylation of key regulatory proteins. Due to its versatile roles, HDAC6 is a promising drug target with potential therapeutic applications in cancer, neurodegenerative diseases, and immune disorders.

References

Strausberg, R.L. et al., Proc. Natl. Acad. Sci. U.S.A. 99 (26), 16899-16903 (2002).