HC Toxin

Catalog #

27209

$145 *

Size: 500 µg

Qty

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Description

HC Toxin is a reversible, cell-permeable inhibitor of HDACs. It is a cyclic tetrapeptide first isolated from C. carbonum, a maize pathogen. It up-regulates the expression of 15-lipoxygenase-1 in colorectal cancer cells and has been shown to induce fetal hemoglobin in human primary erythroid cells.

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Product Info

Storage and Usage

Citations

Purity

≥95% by HPLC.

Format

A crystalline solid

Formula

C₂₂H₃₄N₄O₆

450.5 Da

Solubility

Soluble in methanol, purged with an inert gas. Solubility in methanol is approximately 10 mg/ml. For organic solvent-free aqueous solutions, prepare by directly dissolving the crystalline compound in aqueous buffers.

Biological Activity

HC Toxin inhibits HDACs with an IC50 = 30 nM.

CAS Registry #

83209-65-8

References

1. Brosch, G., et al., Plant Cell. 1995; 7: 1941-1950.
2. Darkin-Rattray, SJ, et al., Proc. Natl. Acad. Sci. USA. 1996; 93(23): 13143-13147.
3. Kamitani, H., et al., Carconogenesis. 2001; 22(1): 187-191.

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HC Toxin

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