HA-1077

Catalog #

27030

$225 *

Size: 250 mg

Qty

Bulk/Custom

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Description

Dihydrochloride form of HA-1077. Inhibits a number of kinases, including ROCK I (IC50 = 10.7 µM), ROCK II (IC50 = 1.9 µM), MAPK1 (IC50 = 5 µM), and PKCRK2 (IC50 = 4 µM). Weaker inhibitor of PKC (IC50 = 425 µM) and MLCK (IC50 = 95 µM) .

This product has been cited 2 times.

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Synonyms

Fasudil, Dihydrochloride Salt, 1-(5-Isoquinolinesulfonyl)homopiperazine, 2HCl, Eril, AT-877

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Product Data Gallery

Product Info

Storage and Usage

Citations2

Purity

≥99%

Format

White crystalline powder.

Formula

C₁₄H₁₇N₃O₂S•2HCl

364.3 Da

Solubility

Very soluble in water, up to 200 mg/ml or more; soluble in DMSO up to about 10 mg/ml; not soluble in ethanol; addition of an aqueous solution of this dihydrochloride salt into a buffer solution may significantly alter its solubility

CAS Registry #

203911-27-7

References

Davies, S.P. et al. Biochem. J. 351: 95-105 (2000).

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HA-1077

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