HA-1077

Catalog #: 27030
Size: 250 mg
$195
MW: 364.3 Da
CAS Registry #: 203911-27-7
Formula: C14H17N3O2S•2HCl
Description:
Dihydrochloride form of HA-1077. Inhibits a number of kinases, including ROCK I (IC50 = 10.7 µM), ROCK II (IC50 = 1.9 µM), MAPK1 (IC50 = 5 µM), and PKCRK2 (IC50 = 4 µM). Weaker inhibitor of PKC (IC50 = 425 µM) and MLCK (IC50 = 95 µM) .
Synonym(s):
Fasudil, Dihydrochloride Salt, 1-(5-Isoquinolinesulfonyl)homopiperazine, 2HCl, Eril, AT-877
Purity:

≥99%

Solubility:
Very soluble in water, up to 200 mg/ml or more; soluble in DMSO up to about 10 mg/ml; not soluble in ethanol; addition of an aqueous solution of this dihydrochloride salt into a buffer solution may significantly alter its solubility
Format:
White crystalline powder.
Storage / Stability:
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Reference(s):
Davies, S.P. et al. Biochem. J. 351: 95-105 (2000).
Scientific Category:
Kinase
Product Type:
Inhibitor
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Product Datasheets

27030_Lot140418.pdf