Fluorogenic HDAC/SIRT substrate 1

Catalog #
50032
$265 *
Size: 500 nmole
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Description

A fluorogenic, acetylated peptide substrate for HDACs and SIRTs. Based on residues 379-382 of p53 (Arg-His-Lys-Lys(Ac), a site of regulatory acetylation by the p300 and CBP acetyltransferases (lysines 381, 382)1-3, it is a suitable substrate for HDAC2, HDAC3, HDAC6; SIRT1, SIRT2 and SIRT3 tested so far. This substrate should be used in conjunction with HDAC or SIRT Developer, respectively.

This product has been cited 7 times.

Synonyms
Fluorogenic HDAC substrate 1, Fluorogenic SIRT substrate 1
Product Info
Storage and Usage
Citations7
Supplied As
5 mM DMSO solution (100 µl)
Format
DMSO solution
References

1. A. Ito et al. (2001) EMBO J. 20 1331.
2. A. Ito et al. (2002) EMBO J. 21 6236.
3. N.A. Barlev et al. (2001) Mol. Cell 8 1243.