Fluorogenic DPP substrate2

Catalog #: 80332
Size: 100 µl
$200
MW: 621.7 Da
CAS Registry #: 88937-61-5
Formula: C30H39N9O6
Description:
The fluorogenic DPP substrate 2 is an Arg-Arg-AMC dipeptide. It can be used as a substrate for activity assays of DPP3. λex 353-380 nm, λem=440-460 nm
Synonym(s):
Z-Arg-Arg-AMC, Z-R-R-AMC, Benzyloxycarbonyl- L-arginyl- L-arginine- 4-methylcoumaryl-7-amide
Supplied As:
0.5 mM solution in DMSO (100 µl)
Format:
DMSO solution
Storage / Stability:

Stable at least 6 months from date of receipt, when stored as directed

Application(s):
Useful for the study of DPP3 activity, and for screening small molecule inhibitors of DPP3 for drug discovery and HTS applications. Can also be used as a substrate for cathepsin B.
Reference(s):

1. Dhanda S. et al., Protein Expr Purif. 2007, 52(2):297-305.
2. Agic D. et al., Bioorg Chem. 2007, 35(2):153-69.

Application Reference(s):
1. Design, synthesis and anti-diabetic activity of triazolotriazine derivatives as dipeptidyl peptidase-4 (DPP-4) inhibitors (2017)

Warning(s):
Protect from direct exposure to light. Avoid freeze/thaw cycles.
Scientific Category:
Protease
Product Type:
Substrate
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