FKBP12, His-tag Recombinant
Catalog #
40550
$415
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Description
Human FKBP12 (FK506 binding protein 1A, transcript variant 12A), GenBank Accession No. NM_054014, full length with N-terminal His-tag, MW= 13.1 kDa, expressed in an E. coli expression system. 5References: 1. Knappe,T.A. et al., J. Mol. Biol. 368 (5), 1458-1468 (2007). 2. Wear,M.A. et al., Protein Expr. Purif. 51 (1), 80-95 (2007).
This product has been cited 2 times.
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Synonyms
FK506 Binding Protein 1, FKBP, Rotamase, Immunophilin FKBP12, PPIase, Calstabin
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Product Data Gallery
14% SDS-PAGE Coomassie Staining
Product Info
Storage and Usage
Citations2
Species
Human
Host Species/Expression System
E. coli
Purity
≥90%
Format
Aqueous buffer solution
Formulation
50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 0.25 mM DTT, 0.1 EGTA, 0.1 mM EDTA, 0.1 mM PMSF, 50% glycerol.
MW
13.1 kDa
Amino Acids
full length
Genbank #
NM_054014
UniProt #
P62942
Background
PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides Keeps in an inactive conformation TGFBR1, the TGF-beta type I serine/threonine kinase receptor, preventing TGF-beta receptor activation in absence of ligand. Recruites SMAD7 to ACVR1B which prevents the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. May modulate the RYR1 calcium channel activity.
References
1. Knappe,T.A. et al., J. Mol. Biol. 368 (5),
1458-1468 (2007).
2. Wear,M.A. et al., Protein Expr. Purif. 51 (1),
80-95 (2007).
Application Reference:
Structure of glutaraldehyde cross-linked ryanodine receptor
(2013)
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