FAP, His-Tag Recombinant
Catalog #
80100
$485
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Description
Human Fibroblast Activation Protein also known as Integral Membrane Serine Protease) encompassing amino acids 29-760(end), This construct contains a C-terminal His-tag (6xHis). The recombinant protein was affinity purified.
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Synonyms
Fibroblast Activation Protein, seprase, Integral Membrane Serine Protease, Surface-Expressed Protease
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Product Data Gallery
4-20% SDS-PAGE Coomassie Staining
FAP Activity
FAP inhibition curve using a fluorogenic assay (#80210). Representative data only; data may vary by lot.
Product Info
Storage and Usage
Citations
Species
Human
Construct
FAP (29-760(end)-His)
Host Species/Expression System
Sf9
Purity
≥90%
Format
Aqueous buffer solution.
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, variable Imidazole, 3 mM DTT, and 20% glycerol.
MW
86 kDa
Amino Acids
29-760(end)
Specific Activity
≥83 pmol/min/µg
Genbank #
NM_004460
UniProt #
Q12884
Background
Fibroblast Activation Protein, or FAP, is a 170 kDa dimer with
dipeptidase activity. FAP expression is seen on activated stromal fibroblasts in >90% of
all human carcinomas, suggesting a role in the development, growth and metastasis of
carcinomas. It is also involved in the control of wound healing and tissue repair.
References
1. Edosada,C.Y. et al., J. Biol. Chem. 281 (11),
7437-7444 (2006).
2. Edosada,C.Y. et al., FEBS Lett. 580 (6), 1581-1586 (2006).
2. Edosada,C.Y. et al., FEBS Lett. 580 (6), 1581-1586 (2006).
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