Entacapone
Catalog #
27621-1
$115
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Description
Entacapone is a second-generation catechol-O-methyltransferase (COMT) inhibitor
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Synonyms
(E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethylprop-2-enamide
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥98% by HPLC
Target(s)
COMT
Formula
C14H15N3O5
MW
305.3 Da
Solubility
Soluble in DMSO 61 mg/ml, water <1 mg/ml, ethanol 2 mg/ml
Biological Activity
Entacapone potently inhibits rat liver total COMT with IC50 and Ki values of 20.1 nM and 10.7 nM respectively. The IC50 values of entacapone against rat liver soluble COMT (S-COMT) and rat liver membrane-bound COMT (MB-COMT) are 14.3 nM and 73.3 nM respectively.
CAS Registry #
130929-57-6
References
Forsberg M, et al. J Pharmacol Exp Ther. 2003 Feb;304(2):498-506.
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