Human EMAP-II Recombinant

Catalog #

90123-A

$130 *

Size: 5 µg

Qty

Bulk/Custom

Add to Favorites

*US Pricing only. For international pricing, please contact your local distributor.

●

Purchase

●

Description

Recombinant EMAP-II is a disulfide-linked monomer protein consisting of 167 amino acid residues, and migrates as an approximately 18 kDa protein under non-reducing and reducing conditions in SDS-PAGE. Optimized DNA sequence encoding Human EMAP-II mature chain was expressed in E. coli.

●

Synonyms

EMAP2, Aminoacyl TRNA Synthetase Complex-Interacting Multifunctional Protein 1, AIMP1, Endothelial Monocyte-Activating Polypeptide 2

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥95% by SDS-PAGE and HPLC

Format

lyophilized protein

Formulation

Lyophilized from 0.2 µm filtered 20 mM phosphate buffer, 130 mM NaCl solution, pH 7.5.

18 kDa

Endotoxin Level

<0.1 ng/µg (1 EU/µg), using the LAL gel clot method.

Amino Acids

146–312

Biological Activity

The ED₅₀ was determined by apoptotic effect on MCF-7 cells using a concentration of 10-50 ng/ml.

Genbank #

Q12904

UniProt #

Q12904

Background

EMAP-II is activated during apoptosis by cleavage of pro-EMAP through caspase-8 and enhances the recruitment of inflammatory cells by its chemotactic properties. Besides its chemotactic effect on inflammatory cells, EMAP-II increases the adhesiveness of coronary artery smooth muscle cells (CASMC) for monocytes. EMAP-II also has anti-angiogenic properties, which are explained by its pro-apoptotic effect on endothelial cells.

References

1. Cardiovasc Res, Feb 2008, 77: 580 - 589.
2. J. Leukoc. Biol., May 2004, 75: 772 - 776.

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Human EMAP-II Recombinant

PRODUCTS

SERVICES

RESOURCES

COMPANY