Droxinostat

Catalog #

27620-1

$165 *

Size: 10 mg

Qty

Bulk/Custom

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Synonyms

NS 41080; 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide

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Product Info

Storage and Usage

Citations

Purity

≥98% by HPLC

Target(s)

HDAC6, HDAC8

Formula

C₁₁H_{14C_lNO₃}

243.7 Da

Solubility

Soluble in DMSO

CAS Registry #

99873-43-5

Background

Droxinostat has shown a potent action against HDAC3, HDAC6, and HDAC8 which are pyrimidyl-hydroxamic acid-dependent histone deacetylases. Droxinostat shows a significant action on gene transcription hence controlling tumor progression. The cells resistant to the caspase mediated apoptotic pathway get sensitized by Droxinostat, hence proving an active agent of introducing death in cancerous cells.

References

1. Bijangi-Vishehsaraei K, et al. Mol Cell Biochem. 2010 Sep;342(1-2):133-42.
2. Wood TE, et al. Mol Cancer Ther. 2010 Jan;9(1):246-56.

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Droxinostat

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