DPY30, His-tag Recombinant

Catalog #

71203

$450 *

Size: 50 µg

Qty

Bulk/Custom

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Synonyms

DPY30, HDPY30

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Product Data Gallery

4-20% SDS-PAGE Coomassie Staining

Product Info

Storage and Usage

Citations

Species

Human

Host Species/Expression System

E. coli

Purity

≥90%

Format

Aqueous buffer solution

Formulation

45 mM Tris-HCl pH 8.0, 124 mM NaCl, 2.4 mM KCk, 225 mM Imidazole, 1 mM TCEP, 1 µM ZnCl₂, 10% Glycerol.

12 kDa

Amino Acids

2–99(end)

Genbank #

NM_032574

UniProt #

Q9C005

Tag(s)

N-terminal His-tag

Background

As part of the MLL1/MLL complex, involved in the methylation of histone H3 at Lys-4, particularly trimethylation. Histone H3 Lys-4 methylation represents a specific tag for epigenetic transcriptional activation. May play some role in histone H3 acetylation. In a teratocarcinoma cell, plays a crucial role in retinoic acid-induced differentiation along the neural lineage, regulating gene induction and H3 Lys-4 methylation at key developmental loci. May also play an indirect or direct role in endosomal transport.

References

1. Xu, Z., et al., J Cell Biol. 2009 Aug 10 ; 186(3) : 343-53
2. Patel, A., et al., J Biol Chem. 2009 Sep 4 ; 284(36) : 24242-56

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Datasheets/Protocols

71203 Lot 190320

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