DNA Polymerase β (POLB), His-tag Recombinant
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Catalog #
21000
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$350
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Description
Human DNA polymerase β (beta), also known as Pol beta and POLB, GenBank Accession No. NM_002690, a.a. 2-335(end), with N-terminal His-tag, expressed in an E. coli cell expression system. MW=39 kDa.
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Synonyms
DNA polymerase beta, Pol beta and POLB, 21000-1, 21000-2
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Product Data Gallery
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
E. coli
Purity
≥80%
Format
Aqueous buffer solution
Formulation
40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 250 mM imidazole, 0.04% Tween-20, and 20% glycerol.
MW
39 kDa
Amino Acids
2–335 (end)
Genbank #
NM_002690
UniProt #
P06746
Background
DNA polymerase involved in base excision and repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the
3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. The protein is normally found in the cytoplasm, but it translocates to the nucleus upon DNA damage.
References
1. Yamtich, J., et al., PLoS Genet. 2012,8(11): E1003052.
2. Wang, K., et al., Cancer Res. 1992,52(17): 4824-4827.