DLK, GST-Tag Recombinant

Catalog #
79345
$485 *
Size: 50 μg
Qty
*US Pricing only. For international pricing, please contact your local distributor.
Purchase
Description

Recombinant Human DLK, also known as MAP3K12, MUK, and ZPK. Genbank Accession #NM_006301, a.a. 1-520, with an N-terminal GST-tag, MW = 61 kDa, expressed in Sf9 cells via a baculovirus expression system.

Synonyms
MAP3K12; MUK; ZPK; ZPKP1; MEKK12; MAP3K12
Product Info
Storage and Usage
Citations
Species
Human
Host Species/Expression System
Sf9 insect cells
Purity
≥75%
Formulation
50 mM Tris-HCl, pH 7.5, 50 mM NaCl, 10mM glutathione, 0.1 mM EDTA, 0.25 mM DTT, 0.1 mM PMSF, 25% glycerol.
MW
94 kDa
Amino Acids
1-520
Genbank #
NM_006301
UniProt #
Q12852
Tag(s)
GST-Tag
Background
DLK or mitogen-activated protein kinase kinase kinase 12 is a transmembrane protein containing six epidermal growth factor repeats and is a serine/threonine protein kinase. DLK is involved in the differentiation of several cell types, including adipocytes. DLK plays a role of a tumor suppressor protein and is predominately expressed in neuronal cells. DLK as an activator of the Jnk pathway. Overexpression of DLK results in activation of Jnk1 and the accumulation of a hyperphosphorylated form of c-Jun (1). Postnatal loss of DLK in stem cells and niche astrocytes has been shown to regulate neurogenesis (2).
References
1. Hirai, S., et al., Oncogene 2011;12:641-650.

2. Ferron, S., et al., Nature. 2011;475:381-385.