Histone H4 peptide (1-21), Dimethyl R3, Biotin-labeled
Catalog #
51200
$230
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Description
Biotinylated histone H4 peptide (a.a. 1-21) asymmetrically di-methylated at Arginine 3. It also contains a C-terminal GG linker, followed by a biotinylated Lys.
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Synonyms
H4R3me2a, Histone H4 Arg3me2 asymmetric
Product Info
Storage and Usage
Citations
Purity
≥95% by HPLC
Supplied As
200 µM solution in water (500 µl)
Format
Aqueous buffer solution
MW
2630.14 Da
Amino Acids
1–21
Genbank #
NM_003548
UniProt #
P62805
Background
Three types of arginine methylation exist in mammalian cells: monomethylarginine (MMA), asymmetric dimethylarginine (ADMA) and symmetric dimethylarginine (SDMA). Type I PRMTs ((CARM1, PRMT1, PRMT2, PRMT3, PRMT6, and PRMT8) catalyze ADMA, while type II PRMTs (e.g. PRMTs 5 and 7) catalyze SDMA. PRMT1 is the primary methyltransferase that deposits the ADMA mark, and it accounts for over 90% of this type of methylation. The Arg3 residue of Histone H4 is a target for PRMT1 methylation. Methylation of histone H4 at Arg3 is an important step in transcriptional activation, and allows for subsequent acetylation of H4 tails by p300.
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