Demethylase(s)

 

Demethylases are enzymes that remove methyl groups from lysine and arginine residues of proteins, the most commonly studied being histone demethylases. Methylation of histones is essential for regulating transcription and maintaining chromatin structure, and demethylases, like all histone modifying enzymes, play an important role in development and gene regulation. All of the demethylases, with the exception of LSD1, contain a catalytic jumonji domain. Many of these enzymes require a cofactor such as FAD, Fe(II), or α-ketoglutarate.

Like, methyltransferases, demethylases exhibit a high level of substrate specificity with respect to their target lysine. In addition, they are sensitive to the specific type of methylation that they recognize and subsequently demethylate. For example, some demethylases are only capable of demethylating mono- and dimethyl substrates, whereas others are capable of demethylating all states of lysine methylation.

Given the critical role that demethylases play in gene regulation, it is not surprising that they have been linked to many human cancers. BPS was the first company to supply active, high purity histone demethylases for life science research. We provide a unique and comprehensive offering of enzymes, assay kits, and inhibitors/activators to meet all of your research needs. Our large portfolio of substrates, which includes and a number of modified histones, makes it easy to study histone demethylase substrate specificity.

References:

1.  Pedersen, M.T., et al., Trends Cell Biol. 2010; 20(11): 662-671.

 

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Catalog#SizeProduct NamePrice
50112 20 µg JARID1C(KDM5C), FLAG-tag
$460
50612 96 reactions JHDM1D (KDM7A) Chemiluminescent Assay Kit
$680
50419 20 µg JHDM1D (KDM7A), FLAG-tag
$435
50130 20 µg JMJD1A (KDM3A), FLAG-tag
$450
50421 20 µg JMJD1B (KDM3B), FLAG-tag
$450
50413 384 reactions JMJD2A (KDM4A) Homogeneous Assay Kit
$1,725
50123 100 µg JMJD2A(KDM4A) (1-350), His-tag
$450
50414 384 reactions JMJD2B (KDM4B) Homogeneous Assay Kit
$1,725
50111 100 µg JMJD2B (KDM4B), GST-tag
$450
50104 100 µg JMJD2B(KDM4B) , FLAG-tag
$450
50405 96 reactions JMJD2C (KDM4C) Chemiluminescent Assay Kit
$660
50415 384 reactions JMJD2C (KDM4C) Homogeneous Assay Kit
$1,725
50105 100 µg JMJD2C, GST-Tag
$450
50418 96 reactions JMJD2D (KDM4D) Chemiluminescent Assay Kit
$660
50117 100 µg JMJD2D (KDM4D), GST-tag
$425
50417 384 reactions JMJD2E (KDM4DL) Homogeneous Assay Kit
$1,725
50118 100 µg JMJD2E (KDM4DL), GST-tag
$450
50406 96 reactions JMJD3 (KDM6B) Chemiluminescent Assay Kit
$680
50416 384 reactions JMJD3 (KDM6B) Homogeneous Assay Kit
$1,725
50115 20 µg JMJD3 (KDM6B), FLAG-tag
$460
50140 20 µg JMJD6, GST-tag
$450
50097 50 µg LSD1 (KDM1A), Variant 2
$435
50100 50 µg LSD1 (KDM1A), Variant 2, GST-tag
$435
50101 500 µl LSD1 Substrate
$195
50204 50 µg LSD1 Variant 1, GST-tag
$450

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