Tranylcypromine (2-PCPA)
Catalog #
27305
$215
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Description
Tranylcypromine (2-PCPA) is an irreversible inhibitor of LSD1 histone demethylase and monoamine oxidases (MAO). The inhibitor targets monoamine oxidases A and B and has been used as a chemical scaffold to design new demethylase inhibitors. Tranylcypromine has been shown to increase Histone H3 lysine 4 (H3K4) methylation in P19 embryonal carcinoma cell.
This product has been cited 4 times.
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Product Info
Storage and Usage
Citations4
Purity
≥98% by HPLC
Format
A white to off white solid
Formula
C18H22N2 •H2SO4
MW
364.5 kDa
Solubility
Soluble in water (25 mg/ml).
Biological Activity
Tranylcypromine inhibits LSD1 with an IC50 value of 20.7 µM and a Ki value of 242.7 µM. It also irreversibly inhibits MAO A and MAO B with IC50 values of 2.3 and 0.95 µM and Ki values of 101.9 and 16 µM, respectively.
CAS Registry #
13492-01-8
References
1. Schmidt, D.M.Z., and McCafferty, D.G. et al. Biochemistry 46:4408-4416 (2007)
2. Yang, M., et al. Biochemistry 46:8058-65(2007)
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