HNHA
Catalog #
27206
$220
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Description
HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity. HNHA induces histone hyperacetylation and p21 transcription with inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. In in vivo murine xenographs, HNHA is equally as effective as SAHA in inhibiting tumor growth. HNHA inhibits HUVEC growth and prevents tube formation and migration in response to VEGF. Also HNHA blocks retinal neovascularization and choroidal angiogenesis in mice.
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥98% by HPLC
Format
A crystalline solid
Formula
C17H21NO2S
MW
303.4 Da
Solubility
Soluble in ethanol, DMSO and dimethyl formamide at 20 mg/ml. Sparingly soluble
in aqueous buffers. First dissolve in DMSO, then dilute with aqueous buffer of choice.
Biological Activity
HDAC is inhibited by HNHA with IC50 = 100 nM.
CAS Registry #
926908-04-5
References
1. Kim, D.H., et al., Biochem. Biophys., Res. Commun. 2007; 356: 233 -328.
2. Kim, J.H., et al., Molecular Pharmaceutics 2009; 6(2): 513-519.
2. Kim, J.H., et al., Molecular Pharmaceutics 2009; 6(2): 513-519.