EX527

Catalog #

27103

$185 *

Size: 1 mg

Qty

Bulk/Custom

Add to Favorites

*US Pricing only. For international pricing, please contact your local distributor.

●

Purchase

●

Description

EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor. It is Selective inhibitor of SIRT1 that does not class I/II inhibit histone deacetylase (HDAC) or other sirtuin deacetylase family members. EX 527 has been used a powerful tool for studying the relationship between SIRT1 and cell regulation.

This product has been cited 1 time.

●

Product Data Gallery

Product Info

Storage and Usage

Citations1

Purity

≥99% by HPLC

Format

White to beige powder.

Formula

C₁₃H₁₃ClN_2O

248.7 Da

Solubility

Soluble in DMSO.

Biological Activity

EX-527 inhibits SIRT1 class III histone deacetylase enzyme inhibitor with an IC50 of 38 nM. IC50 values are 98 nM, 19.6 µM, 48.7 µM, >100 µM and > 100 µM for SIRT1, SIRT2, SIRT3, HDAC and NADase respectively.

CAS Registry #

49843-98-3

References

1. Solomon, JM et al. Mol Cell Biol. 2006 Jan;26(1):28-38
2. Huhtiniemi, T et al. J Med Chem. 2008 Aug 14;51(15):4377-80

Skip to the end of the images gallery

Skip to the beginning of the images gallery

EX527

PRODUCTS

SERVICES

RESOURCES

COMPANY