Droxinostat
Catalog #
27620-1
$165
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Synonyms
NS 41080; 4-(4-Chloro-2-methylphenoxy)-N-hydroxybutanamide
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Product Data Gallery
Product Info
Storage and Usage
Citations
Purity
≥98% by HPLC
Target(s)
HDAC6, HDAC8
Formula
C11H14ClNO3
MW
243.7 Da
Solubility
Soluble in DMSO
CAS Registry #
99873-43-5
Background
Droxinostat has shown a potent action against HDAC3, HDAC6, and HDAC8 which are pyrimidyl-hydroxamic acid-dependent histone deacetylases. Droxinostat shows a significant action on gene transcription hence controlling tumor progression. The cells resistant to the caspase mediated apoptotic pathway get sensitized by Droxinostat, hence proving an active agent of introducing death in cancerous cells.
References
1. Bijangi-Vishehsaraei K, et al. Mol Cell Biochem. 2010 Sep;342(1-2):133-42.
2. Wood TE, et al. Mol Cancer Ther. 2010 Jan;9(1):246-56.
2. Wood TE, et al. Mol Cancer Ther. 2010 Jan;9(1):246-56.