CI-994

Catalog #

27021

$155 *

Size: 50 mg

Qty

Bulk/Custom

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Description

CI-994 is a histone deacetylase (HDAC) inhibitor that induces histone hyperacetylation. CI-994 inhibited HDAC-1 and HDAC-2 but not GCN5. CI-994 is also a novel antitumor agent, exhibiting activity against pancreatic, colon and mammary tumors. CI-994 inhibited the growth of two non-small cell lung cancer cell lines, A-549 (adenocarcinoma) and LX-1 (squamous cell carcinoma), with an IC50 of 80 µM.

This product has been cited 2 times.

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Synonyms

Acetyldinaline, Gö 5549, PD 123654, Tacedinaline

Product Info

Storage and Usage

Citations2

Purity

≥99%

Format

White to off-white powder

Formula

C₁₅H₁₅N₃O₂

269.3 Da

Solubility

Soluble in DMSO at 66 mg/ml; very poorly soluble in ethanol; very poorly soluble in water; maximum solubility in plain water is estimated to be about 25-100 µM; buffers, serum, or other additives may increase or decrease the aqueous solubility.

CAS Registry #

112522-64-2

References

1. Kraker, A.J., et al. Mol. Cancer Ther. 2: 401-408 (2003).
2. LoRusso, P.M., et al. Invest. New Drugs 14: 349-356 (1996).
3. Loprevite, M., et al. Oncol. Res. 15: 39-48 (2005).

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